![]() Facilitation of self-stimulation behavior following intracerebral microinjections of opioids into the ventral tegmental area. Annals of Clinical Psychiatry, 14, 9–15.īroekkamp, C.L. ![]() A pilot placebo-controlled study of fluvoxamine for pathological gambling. American Journal of Psychiatry, 153, 119–121.īlanco, C., Petkova, E., Ibanez, A., & Sáiz-Ruiz, J. Pathological gambling and platelet MAO activity: a psychobiological study. Pathological gambling: addiction or compulsion? Seminars in Clinical Neuropsychiatry, 6, 167–176.īlanco, C., Orensanz-Munoz, L., Blanco-Jerez, C., & Saiz-Ruiz, J. American Journal of Mental Retardation, 93, 644–651.īlanco, C., Moreyra, P., Nunes, E.V., Sáiz-Ruiz, J., & Ibánez, A. Effects of naloxone and naltrexone on self-injury: a double-blind, placebo-controlled analysis. Washington, D.C.: American Psychiatric Association.īarrett, R.P., Feinstein, C., & Hole, W.T. Diagnostic and statistical manual of mental disorders (4 th Ed.-Text Revision). Washington, D.C.: American Psychiatric Association.Īmerican Psychiatric Association Committee on Nomenclature and Statistics. Diagnostic and statistical manual of mental disorders (3rd Ed.-Revised). ![]() Diagnostic and statistical manual of mental disorders (3rd Ed.). American Journal of Psychiatry, 151, 780–781.Īmerican Psychiatric Association Committee on Nomenclature and Statistics. Decreased substance use in chronically psychotic patients treated with clozapine. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society.Albanese, M.J., Khantzian, E.J., Murphy, S.L., & Green, A.I. Identification of factors related to treatment response will help inform future studies and advance treatment strategies for PG.Īddiction gambling impulsivity pharmacology. Heterogeneity of PG treatment samples may also complicate identification of effective treatments. Response measures have varied across studies. those without co-occurring psychiatric disorders). Most published studies, however, have employed relatively small sample sizes, are of limited duration and involve possibly non-representative clinical groups (e.g. Given that several studies have demonstrated their efficacy in treating the symptoms associated with PG, opioid antagonists should be considered the first line treatment for PG at this time. Although limited information is available, opioid antagonists and glutamatergic agents have demonstrated efficacious outcomes, especially for individuals with PG suffering from intense urges to engage in the behaviour. Antidepressants, atypical antipsychotics and mood stabilizers have demonstrated mixed results in controlled clinical trials. A variety of medication classes have been examined in the treatment of PG with varying results. Study outcome and the mean dose of medication administered was documented in an effort to determine a preferred medication choice in this population. A systematic review of the 18 double-blind, placebo-controlled pharmacotherapy studies conducted for the treatment of pathological gambling was conducted. ![]() This review seeks to examine the history of medication treatments for PG. Although common and financially devastating to individuals and families, there currently exist no formally approved pharmacotherapeutic interventions for this disorder. Pathological gambling (PG) is a relatively common and often disabling psychiatric condition characterized by intrusive urges to engage in deleterious gambling behaviour. ![]()
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